Dr Paul Kemp

Publications


Journals

  • Jackson AS; Shrikrishna D; Kelly JL; Hart N; Moxham J; Polkey MI; Kemp P; Hopkinson NS. (3 May 2012). Vitamin D and skeletal muscle strength and endurance in chronic obstructive pulmonary disease. Eur Respir J. DOI.
  • Riddoch-Contreras J; George T; Natanek SA; Marsh GS; Hopkinson NS; Tal-Singer R; Kemp P; Polkey MI. (Apr 2012). p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease. COPD. 9:142-150. DOI.
  • Shrikrishna D; Patel M; Tanner RJ; Seymour JM; Connolly BA; Puthucheary ZA; Walsh SL; Bloch SA; et alSidhu PS; Hart N; Kemp PR; Moxham J; Polkey MI; Hopkinson NS. (23 Feb 2012). Quadriceps wasting and physical inactivity in patients with COPD. Eur Respir J. DOI.
  • Lee JY; Hopkinson NS; Kemp PR. (2 Dec 2011). Myostatin induces autophagy in skeletal muscle in vitro. Biochem Biophys Res Commun. 415:632-636. DOI.
  • Bloch S; Polkey MI; Griffiths M; Kemp P. (Apr 2012). Molecular mechanisms of intensive care unit-acquired weakness. Eur Respir J. 39:1000-1011. DOI.
  • Lewis A; Riddoch-Contreras J; Natanek SA; Donaldson A; Man WD; Moxham J; Hopkinson NS; Polkey MI; et alKemp PR. (Jan 2012). Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax. 67:26-34. DOI.
  • Hyde MJ; Mostyn A; Modi N; Kemp PR. (Feb 2012). The health implications of birth by Caesarean section. Biol Rev Camb Philos Soc. 87:229-243. DOI.
  • Natanek SA; Riddoch-Contreras J; Marsh GS; Hopkinson NS; Man WD; Moxham J; Polkey MI; Kemp PR. (Jun 2011). Yin Yang 1 expression and localisation in quadriceps muscle in COPD. Arch Bronconeumol. 47:296-302. DOI.
  • Hyde MJ; Clarke L; Griffin JL; Herrera E; Byrne CD; Kemp PR. (1 Mar 2011). A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets. METABOLOMICS. 7:118-125. DOI.
  • Harling L; Warren OJ; Martin A; Kemp PR; Evans PC; Darzi A; Athanasiou T. (May 2011). Do miniaturized extracorporeal circuits confer significant clinical benefit without compromising safety? A meta-analysis of randomized controlled trials. ASAIO J. 57:141-151. DOI.
  • Man W-C; Natanek SA; Riddoch-Contreras J; Lewis A; Marsh GS; Kemp PR; Polkey MI. Quadriceps myostatin expression in COPD. European Respiratory Journal. 36:686-688.
  • Shore A; Karamitri A; Kemp P; Speakman JR; Lomax MA. (Jun 2010). Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia. 53:1164-1173. DOI.
  • Amirak E; Zakkar M; Evans PC; Kemp PR. (1 Jan 2010). Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 391:818-823. DOI.
  • Hyde MJ; Griffin JL; Herrera E; Byrne CD; Clarke L; Kemp PR. (Jan 2010). Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets. Clin Sci (Lond). 118:47-59. DOI.
  • Man WD; Kemp P; Moxham J; Polkey MI. (2009). Skeletal muscle dysfunction in COPD: clinical and laboratory observations. Clinical Science (Lond). 117:251-264.
  • Man WD; Kemp P; Moxham J; Polkey MI. (2009). Exercise and muscle dysfunction in COPD: implications for pulmonary rehabilitation. Clinical Science (Lond). 117:281-291.
  • Sathyapala SA; Kemp P; Polkey MI. (2007). Decreased muscle PPAR concentrations: a mechanism underlying skeletal muscle abnormalities in COPD?. Europeran Respir Journal. 30:191-193.
  • Outram SV; Gordon AR; Hager-Theodorides AL; Metcalfe J; Crompton T; Kemp P. (1 Jul 2008). KLF13 influences multiple stages of both B and T cell development. CELL CYCLE. 7:2047-2055. Author weblink DOI.
  • Gordon AR; Outram SV; Keramatipour M; Goddard CA; Colledge WH; Metcalfe JC; Hager-Theodorides AL; Crompton T; et alKemp PR. (2 May 2008). Splenomegaly and modified erythropoiesis in KLF13(-/-) mice. JOURNAL OF BIOLOGICAL CHEMISTRY. 283:11897-11904. Author weblink DOI.
  • Favot L; Hall SM; Haworth SG; Kemp PR. (1 Dec 2005). Cytoplasmic YY1 is associated with increased smooth muscle-specific gene expression - Implications for neonatal pulmonary hypertension. AMERICAN JOURNAL OF PATHOLOGY. 167:1497-1509. Author weblink DOI.
  • Kemp PR; Ellis PD; Smith CW. (Dec 2005). Visualization of alternative splicing in vivo. Methods. 37:360-367. DOI.
  • Favot L; Gillingwater M; Scott C; Kemp PR. (3 Jan 2005). Overexpression of a family of RPEL proteins modifies cell shape. FEBS Lett. 579:100-104. DOI.
  • Gordon AR; Metcalfe J; Kemp PR. (1 Dec 2004). Alternative splicing of serum response factor. HEART. 90. Author weblink.
  • Keramatipour M; Goddard CA; Colledge WH; Kemp PR. (1 Dec 2004). Hypertension and cardiac hypertrophy in BTEB3 null mice. HEART. 90. Author weblink.
  • Ellis PD; Smith CW; Kemp P. (27 Aug 2004). Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by alpha-tropomyosin regulatory elements in transgenic mice. J Biol Chem. 279:36660-36669. DOI.
  • Martin KM; Ellis PD; Metcalfe JC; Kemp PR. (15 Oct 2003). Selective modulation of the SM22alpha promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats. Biochem J. 375:457-463. DOI.
  • Dunning AM; Ellis PD; McBride S; Kirschenlohr HL; Healey CS; Kemp PR; Luben RN; Chang-Claude J; et alMannermaa A; Kataja V; Pharoah PD; Easton DF; Ponder BA; Metcalfe JC. (15 May 2003). A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res. 63:2610-2615.
  • Ellis PD; Metcalfe JC; Hyvönen M; Kemp PR. (May 2003). Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1. J Vasc Res. 40:234-243. DOI.
  • Gooding C; Kemp P; Smith CW. (25 Apr 2003). A novel polypyrimidine tract-binding protein paralog expressed in smooth muscle cells. J Biol Chem. 278:15201-15207. DOI.
  • Ellis PD; Martin KM; Rickman C; Metcalfe JC; Kemp PR. (1 Jun 2002). Increased actin polymerization reduces the inhibition of serum response factor activity by Yin Yang 1. Biochem J. 364:547-554. DOI.
  • Lu Y; Mahaut-Smith MP; Varghese A; Huang CL; Kemp PR; Vandenberg JI. (15 Dec 2001). Effects of premature stimulation on HERG K(+) channels. J Physiol. 537:843-851.
  • Martin KM; Metcalfe JC; Kemp PR. (May 2001). Expression of Klf9 and Klf13 in mouse development. Mech Dev. 103:149-151.
  • Lücke CD; Philpott A; Metcalfe JC; Thompson AM; Hughes-Davies L; Kemp PR; Hesketh R. (15 Jan 2001). Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer. Cancer Res. 61:482-485.
  • Yang Y; Beqaj S; Kemp P; Ariel I; Schuger L. (1 Dec 2000). Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. JOURNAL OF CLINICAL INVESTIGATION. 106:1321-1330. Author weblink DOI.
  • Ellis PD; Chen Q; Barker PJ; Metcalfe JC; Kemp PR. (Aug 2000). Nov gene encodes adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to vascular injury. Arterioscler Thromb Vasc Biol. 20:1912-1919.
  • Kemp PR; Metcalfe JC. (1 Feb 2000). Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity. Biochem J. 345 Pt 3:445-451.
  • Martin KM; Cooper WN; Metcalfe JC; Kemp PR. (1 Feb 2000). Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions. BIOCHEMICAL JOURNAL. 345:529-533. Author weblink DOI.
  • Grainger DJ; Heathcote K; Chiano M; Snieder H; Kemp PR; Metcalfe JC; Carter ND; Spector TD. (Jan 1999). Genetic control of the circulating concentration of transforming growth factor type beta1. Hum Mol Genet. 8:93-97.
  • Russell MW; Kemp P; Wang LH; Brody LC; Izumo S. (22 Dec 1998). Molecular cloning of the human HAND2 gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. 1443:393-399. Author weblink DOI.
  • Syrris P; Carter ND; Metcalfe JC; Kemp PR; Grainger DJ; Kaski JC; Crossman DC; Francis SE; et alGunn J; Jeffrey S; Heathcote K. (1 Dec 1998). Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLINICAL SCIENCE. 95:659-667. Author weblink.
  • Oklü R; Hesketh TR; Metcalfe JC; Kemp PR. (18 Sep 1998). Expression of alternatively spliced human latent transforming growth factor beta binding protein-1. FEBS Lett. 435:143-148.
  • Horner A; Kemp P; Summers C; Bord S; Bishop NJ; Kelsall AW; Coleman N; Compston JE. (Aug 1998). Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone. Bone. 23:95-102.
  • Oklü R; Metcalfe JC; Hesketh TR; Kemp PR. (27 Mar 1998). Loss of a consensus heparin binding site by alternative splicing of latent transforming growth factor-beta binding protein-1. FEBS Lett. 425:281-285.
  • Horner A; Bord S; Kemp P; Grainger D; Compston JE. (Oct 1996). Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone. Bone. 19:353-362.
  • Kemp PR; Osbourn JK; Grainger DJ; Metcalfe JC. (15 Sep 1995). Cloning and analysis of the promoter region of the rat SM22 alpha gene. Biochem J. 310 ( Pt 3):1037-1043.
  • KEMP PR; OSBOURN JK; GRAINGER DJ; METCALFE JC. (15 Sep 1995). CLONING AND ANALYSIS OF THE PROMOTER REGION OF THE RAT SM22-ALPHA GENE. BIOCHEMICAL JOURNAL. 310:1037-1043. Author weblink.
  • Kemp PR; Metcalfe JC; Grainger DJ. (10 Jul 1995). ID--a dominant negative regulator of skeletal muscle differentiation--is not involved in maturation or differentiation of vascular smooth muscle cells. FEBS Lett. 368:81-86.
  • Grainger DJ; Mosedale DE; Metcalfe JC; Weissberg PL; Kemp PR. (28 Feb 1995). Active and acid-activatable TGF-beta in human sera, platelets and plasma. Clin Chim Acta. 235:11-31.
  • Grainger DJ; Kemp PR; Metcalfe JC; Liu AC; Lawn RM; Williams NR; Grace AA; Schofield PM; et alChauhan A. (Jan 1995). The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis. Nat Med. 1:74-79.
  • Grainger DJ; Kemp PR; Liu AC; Lawn RM; Metcalfe JC. (11 Aug 1994). Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice. Nature. 370:460-462. DOI.
  • Grainger DJ; Kemp PR; Witchell CM; Weissberg PL; Metcalfe JC. (1 Apr 1994). Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase. Biochem J. 299 ( Pt 1):227-235.
  • GRAINGER DJ; KEMP PR; WITCHELL CM; WEISSBERG PL; METCALFE JC. (1 Apr 1994). TRANSFORMING GROWTH-FACTOR-BETA DECREASES THE RATE OF PROLIFERATION OF RAT VASCULAR SMOOTH-MUSCLE CELLS BY EXTENDING THE G(2) PHASE OF THE CELL-CYCLE AND DELAYS THE RISE IN CYCLIC-AMP BEFORE ENTRY INTO M-PHASE. BIOCHEMICAL JOURNAL. 299:227-235. Author weblink.
  • Kemp PR; Shachar-Hill Y; Weissberg PL; Metcalfe JC. (20 Dec 1993). Inhibition of PDGF BB stimulated DNA synthesis in rat aortic vascular smooth muscle cells by the expression of a truncated PDGF beta receptor. FEBS Lett. 336:119-123.
  • Kemp PR; Grainger DJ; Shanahan CM; Weissberg PL; Metcalfe JC. (1 Jul 1991). The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells. Biochem J. 277 ( Pt 1):285-288.
  • KEMP PR; GRAINGER DJ; SHANAHAN CM; WEISSBERG PL; METCALFE JC. (1 Jul 1991). THE ID GENE IS ACTIVATED BY SERUM BUT IS NOT REQUIRED FOR DEDIFFERENTIATION IN RAT VASCULAR SMOOTH-MUSCLE CELLS. BIOCHEMICAL JOURNAL. 277:285-288. Author weblink.

Conferences

  • Donaldson AVJ; Lewis A; Natanek A; Man WD; Kemp P; Polkey MI. INCREASED SKELETAL MUSCLE-SPECIFIC MICRORNA-1 IN THE BLOOD OF COPD PATIENTS. Winter Meeting of the British-Thoracic-Society, 7 Dec 2011 - 9 Dec 2011. 66:A25-A25. B M J PUBLISHING GROUP (1 Dec 2011). Author weblink DOI.
  • Natanek SA; Langen RCJ; Gosker HR; Marsh GS; Slot I; Hopkinson NS; Man WD-C; Kemp PR; et alMoxham J; Schols AMWJ; Polkey MI. NF-KAPPA B (NF-kappa B) AND ACTIVATOR PROTEIN-1 (AP-1) DNA BINDING IN THE QUADRICEPS OF COPD PATIENTS. 65:A138-A139. B M J PUBLISHING GROUP (1 Dec 2010). DOI.
  • Natanek SA; Gosker HR; Slot I; Marsh GS; Langen RCJ; Hopkinson NS; Man WD-C; Moxham J; et alKemp PR; Schols AMWJ; Polkey MI. MUSCLE FIBRE ATROPHY AND AEROBIC TO ANAEROBIC FIBRE TYPE SHIFT IN THE QUADRICEPS IN COPD. 65:A139-A139. B M J PUBLISHING GROUP (1 Dec 2010). DOI.
  • Man WD; Sathyapala SA; Riddoch-Contreras J; Lewis A; Marsh G; Polkey MI; Kemp PR. QUADRICEPS MUSCLE EXPRESSION OF MYOSTATIN IN PATIENTS WITH COPD. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A39-A39. B M J PUBLISHING GROUP (1 Dec 2009). DOI.
  • Lewis A; Sathyapala SA; Riddoch-Contreras J; Man WDC; Marsh GS; Polkey MI; Hopkinson NS; Kemp PR. REDUCED EXPRESSION AND ACTIVITY OF MYOCARDIN-RELATED TRANSCRIPTION FACTORS CONTRIBUTES TO FIBRE TYPE CHANGES IN THE QUADRICEPS OF PATIENTS WITH COPD. Winter Meeting of the British-Thoracic-Society, 2 Dec 2009 - 4 Dec 2009. 64:A134-A134. B M J PUBLISHING GROUP (1 Dec 2009). DOI.
  • Contreras JR; Sathyapala SA; Marsh GS; Polkey MI; Kemp PR. FOUR AND A HALF LIM PROTEIN 1 EXPRESSION AND AKT PHOSPHORYLATION IN QUADRICEPS MUSCLE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS AND ITS RELATION TO MUSCLE STRENGTH AND PHYSICAL ACTIVITY. Winter Meeting of the British-Thoracic-Society, 3 Dec 2008 - 5 Dec 2008. 63:A24-A24. B M J PUBLISHING GROUP (1 Dec 2008). Author weblink.
  • Sathyapala SA; Marsh GS; Hopkinson NS; Moxham J; Kemp P; Polkey MI. Muscle ring finger protein 1 (MuRF-1), atrogin-1 and muscle wasting in COPD. Winter Meeting of the British-Thoracic-Society, 5 Dec 2007 - 7 Dec 2007. 62:A137-A138. B M J PUBLISHING GROUP (1 Dec 2007). Author weblink.
  • Keramatipour M; Ellis PD; Grace AA; Metcalfe JC; Kemp PR. The role of transcription factor BTEB3 in the regulation of smooth muscle-specific gene expression in vivo. Annual Meeting of the American-Society-of-Human-Genetics, 4 Nov 2003 - 8 Nov 2003. 73:343-343. UNIV CHICAGO PRESS (1 Nov 2003). Author weblink.
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