Publications

Journals

• Zhou W; Brand NJ; Ying L. (Jun 2011). G-quadruplexes-novel mediators of gene function. J Cardiovasc Transl Res. 4:256-270. DOI.
• Lenn T; Gkekas C; Bernard L; Engl C; Jovanovic G; Buck M; Ying LM. (2011). Measuring the stoichiometry of functional PspA complexes in living bacterial cells by single molecule photobleaching. Chemical Communications. 47:400-402.
• Zhou W-H; Ying L-M. (1 Apr 2010). Single Molecule Fluorescence Resonance Energy Transfer and Ensemble Biophysical Characterization of a G-quadruplex Formed in the Promoter of Human Myocyte Enhancer Factor 2D. ACTA PHYSICO-CHIMICA SINICA. 26:1099-1106. Author weblink.
• Fegan A; Shirude PS; Ying LM; Balasubramanian S. (14 Feb 2010). Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes. CHEM COMMUN. 46:946-948. DOI.
• Huang F; Rajagopalan S; Settanni G; Marsh RJ; Armoogum DA; Nicolaou N; Bain AJ; Lerner E; et alHaas E; Ying L; Fersht AR. (8 Dec 2009). Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:20758-20763. DOI.
• Huang F; Ying L; Fersht AR. (22 Sep 2009). Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:16239-16244. Author weblink DOI.
• Ko CW; Wei Z; Marsh RJ; Armoogum DA; Nicolaou N; Bain AJ; Zhou A; Ying L. (1 Jan 2009). Probing nanosecond motions of plasminogen activator inhibitor-1 by time-resolved fluorescence anisotropy. MOLECULAR BIOSYSTEMS. 5:1025-1031. Author weblink DOI.
• Engl C; Jovanovic G; Lloyd LJ; Murray H; Spitaler M; Ying L; Errington J; Buck M. (1 Aug 2009). In vivo localizations of membrane stress controllers PspA and PspG in Escherichia coli. MOLECULAR MICROBIOLOGY. 73:382-396. Author weblink DOI.
• Piper JD; Li C; Lo C-J; Berry R; Korchev Y; Ying L; Klenerman D. (6 Aug 2008). Characterization and application of controllable local chemical changes produced by reagent delivery from a nanopipet. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 130:10386-10393. Author weblink DOI.
• Shirude PS; Ying L; Balasubramanian S. (7 May 2008). Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC. CHEMICAL COMMUNICATIONS. 2007-2009. Author weblink DOI.
• Li C; Johnson N; Ostanin V; Shevchuk A; Ying L; Korchev Y; Klenerman D. (10 Jun 2008). High resolution imaging using scanning ion conductance microscopy with improved distance feedback control. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL. 18:671-677. Author weblink DOI.
• Zhou D; Ying L; Hong X; Hall EA; Abell C; Klenerman D. (4 Mar 2008). A compact functional quantum dot-DNA conjugate: Preparation, hybridization, and specific label-free DNA detection. LANGMUIR. 24:1659-1664. Author weblink DOI.
• Shirude PS; Okumus B; Ying L; Ha T; Balasubramanian S. (20 Jun 2007). Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene C-kit. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 129:7484-+. Author weblink DOI.
• Ying L. (1 Jan 2007). Single molecule biology: Coming of age. MOLECULAR BIOSYSTEMS. 3:377-380. Author weblink DOI.
• Clarke RW; Piper JD; Ying L; Klenerman D. (11 May 2007). Surface conductivity of biological macromolecules measured by nanopipette dielectrophoresis. PHYSICAL REVIEW LETTERS. 98. Author weblink DOI.
• Huang F; Sato S; Sharpe TD; Ying L; Fersht AR. (2 Jan 2007). Distinguishing between cooperative and unimodal downhill protein folding. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 104:123-127. Author weblink DOI.
• Piper JD; Clarke RW; Korchev YE; Ying L; Klenerman D. (27 Dec 2006). A renewable nanosensor based on a glass nanopipette. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128:16462-16463. Author weblink DOI.
• White SS; Li H; Marsh RJ; Piper JD; Leonczek ND; Nicolaou N; Bain AJ; Ying L; et alKlenerman D. (6 Sep 2006). Characterization of a single molecule DNA switch in free solution. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128:11423-11432. Author weblink DOI.
• Green JJ; Ladame S; Ying L; Klenerman D; Balasubramanian S. (2 Aug 2006). Investigating a quadruplex-ligand interaction by unfolding kinetics. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128:9809-9812. Author weblink DOI.
• Ying LM; Zhou DJ; Bruckbauer A. (19 May 2006). Comment on "trapping single molecules by dielectrophoresis". PHYSICAL REVIEW LETTERS. 96. Author weblink DOI.
• Ren XJ; Li HT; Clarke RW; Alves DA; Ying LM; Klenerman D; Balasubramanian S. (19 Apr 2006). Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 128:4992-5000. Author weblink DOI.
• White SS; Balasubramanian S; Klenerman D; Ying L. (1 Jan 2006). A simple nanomixer for single-molecule kinetics measurements. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 45:7540-7543. Author weblink DOI.
• Zhou DJ; Piper JD; Abell C; Klenerman D; Kang DJ; Ying LM. (1 Jan 2005). Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. CHEMICAL COMMUNICATIONS. 4807-4809. Author weblink DOI.
• Ying LM; Bruckbauer A; Zhou DJ; Gorelik J; Shevehuk A; Lab M; Korchev Y; Klenerman D. (1 Jan 2005). The scanned nanopipette: A new tool for high resolution bioimaging and controlled deposition of biomolecules. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 7:2859-2866. Author weblink DOI.
• Clarke RW; White SS; Zhou DJ; Ying LM; Klenerman D. (1 Jan 2005). Trapping of proteins under physiological conditions in a nanopipette. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 44:3747-3750. Author weblink DOI.
• Li HT; Ren XJ; Ying LM; Balasubramanian S; Klenerman D. (5 Oct 2004). Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 101:14425-14430. Author weblink DOI.
• Bruckbauer A; Zhou DJ; Ying LM; Abell C; Klenerman D. (1 Oct 2004). A simple voltage controlled enzymatic nanoreactor produced in the tip of a nanopipet. NANO LETTERS. 4:1859-1862. Author weblink DOI.
• Ying LM; White SS; Bruckbauer A; Meadows L; Korchev YE; Klenerman D. (1 Feb 2004). Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. BIOPHYSICAL JOURNAL. 86:1018-1027. Author weblink.
• White SS; Ying LM; Balasubramanian S; Klenerman D. (1 Jan 2004). Individual molecules of dye-labeled DNA act as a reversible two-color switch upon application of an electric field. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 43:5926-5930. Author weblink DOI.
• Ying LM; Green JJ; Li HT; Klenerman D; Balasubramanian S. (9 Dec 2003). Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 100:14629-14634. Author weblink DOI.
• Ren XJ; Gavory G; Li HT; Ying LM; Klenerman D; Balasubramanian S. (15 Nov 2003). Identification of a new RNA center dot RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. NUCLEIC ACIDS RESEARCH. 31:6509-6515. Author weblink DOI.
• Zhou D; Bruckbauer A; Ying LM; Abell C; Klenerman D. (1 Nov 2003). Building three-dimensional surface biological assemblies on the nanometer scale. NANO LETTERS. 3:1517-1520. Author weblink DOI.
• Bruckbauer A; Zhou DJ; Ying LM; Korchev YE; Abell C; Klenerman D. (13 Aug 2003). Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 125:9834-9839. Author weblink DOI.
• Green JJ; Ying LM; Klenerman D; Balasubramanian S. (2 Apr 2003). Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 125:3763-3767. Author weblink DOI.
• Li HT; Ying LM; Green JJ; Balasubramanian S; Klenerman D. (1 Apr 2003). Ultrasensitive coincidence fluorescence detection of single DNA molecules. ANALYTICAL CHEMISTRY. 75:1664-1670. Author weblink DOI.
• Bruckbauer A; Ying LM; Rothery AM; Zhou DJ; Shevchuk AI; Abell C; Korchev YE; Klenerman D. (31 Jul 2002). Writing with DNA and protein using a nanopipet for controlled delivery. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 124:8810-8811. Author weblink DOI.
• Bruckbauer A; Ying LM; Rothery AM; Korchev YE; Klenerman D. (1 Jun 2002). Characterization of a novel light source for simultaneous optical and scanning ion conductance microscopy. ANALYTICAL CHEMISTRY. 74:2612-2616. Author weblink DOI.
• Green J; Ying LM; Klenerman D; Blasubramanian S. (1 May 2002). Single-molecule FRET study of DNA G-quadruplex. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES. 18:103-106. Author weblink.
• Ying LM; Bruckbauer A; Rothery AM; Korchev YE; Klenerman D. (15 Mar 2002). Programmable delivery of DNA through a nanopipet. ANALYTICAL CHEMISTRY. 74:1380-1385. Author weblink DOI.
• Wallace MI; Ying LM; Balasubramanian S; Klenerman D. (8 May 2001). Non-Arrhenius kinetics for the loop closure of a DNA hairpin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 98:5584-5589. Author weblink DOI.
• Ying LM; Wallace MI; Klenerman D. (2 Feb 2001). Two-state model of conformational fluctuation in a DNA hairpin-loop. CHEMICAL PHYSICS LETTERS. 334:145-150. Author weblink DOI.
• Wallace MI; Ying LM; Balasubramanian S; Klenerman D. (7 Dec 2000). FRET fluctuation spectroscopy: Exploring the conformational dynamics of a DNA hairpin loop. JOURNAL OF PHYSICAL CHEMISTRY B. 104:11551-11555. Author weblink DOI.
• Ying LM; Wallace MI; Balasubramanian S; Klenerman D. (1 Jun 2000). Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA. JOURNAL OF PHYSICAL CHEMISTRY B. 104:5171-5178. Author weblink DOI.
• Liu TT; Luo GB; Ying LM; Zhao XS. (1 May 2000). Single-molecule detection studies of diffusion of rhodamine-labeled phospholipids. ACTA PHYSICO-CHIMICA SINICA. 16:393-397. Author weblink.
• Luo GB; Liu TT; Ying LM; Zhao XS; Huang YY; Wu DG; Huang CH. (18 Apr 2000). Aggregation and self-organization of a chromophore-labeled double-chain amphiphile. LANGMUIR. 16:3651-3659. Author weblink DOI.
• Wei TX; Shi YR; Zhai J; Gan LB; Huang CH; Liu TT; Ying LM; Luo GB; et alZhao XS. (10 Mar 2000). Synthesis, monolayer fabrication and photoelectric conversion property of two pyrrolidinofullerene carboxylic acid derivatives. CHEMICAL PHYSICS LETTERS. 319:7-12. Author weblink DOI.
• Wei TX; Zhai J; Ge J; Gan LB; Huang CH; Luo GB; Ying LM; Liu TT; et alZhao XS. (15 Feb 2000). Fabrication and Characterization of a New Self-Assembled Monolayer of Fullerene Dicarboxylic Acid Derivative and Its Photoelectric Conversion Property. J Colloid Interface Sci. 222:262-264. DOI.
• Liu TT; Yu AC; Luo GB; Zhao XS; Ying LM; Huang YY; Huang CH. (1 Jan 2000). Aggregates in rhodamine-labeled phospholipid films probed by spectroscopy and atomic force microscopy. ACTA PHYSICO-CHIMICA SINICA. 16:49-54. Author weblink.
• Yu AC; Liu TT; Luo GB; Ying LM; Zhao XS; Huang YY; Huang CH. (1 Jan 2000). Interaction between nitric oxide and lipid-like DDPA LB film investigated with SHG and AFM. CHINESE JOURNAL OF CHEMISTRY. 18:25-28. Author weblink.
• Li M; Zhang XX; Ying LM; Zhao XS. (1 Dec 1999). Reaction mechanism of NO2 determination by the TEA method. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE. 20:1940-1944. Author weblink.
• Chen JY; Huang L; Ying LM; Luo GB; Zhao XS; Cao WX. (12 Oct 1999). Self-assembly ultrathin films based on diazoresins. LANGMUIR. 15:7208-7212. Author weblink DOI.
• Wei TX; Zhai J; Ge JH; Gan LB; Huang CH; Luo GB; Ying LM; Liu TT; et alZhao XS. (1 Sep 1999). Fabrication and their photoelectric conversion properties of two kinds of self-assembled monolayers and Langmuir-Blodgett film of mono-substituted C-60-malonic acid. APPLIED SURFACE SCIENCE. 151:153-158. Author weblink DOI.
• Wu DG; Huang CH; Huang YY; Gan LB; Yu AC; Ying LM; Zhao XS. (26 Aug 1999). Photoelectric generation and second-order nonlinear optical characters of the dichromophore dye molecules. JOURNAL OF PHYSICAL CHEMISTRY B. 103:7130-7134. Author weblink DOI.
• Luo GB; Liu TT; Yu AC; Zhao XS; Ying LM; Wu DG; Huang CH. (1 May 1999). Self-organization of a double chain amphiphile DDPA investigated by AFM. ACTA PHYSICO-CHIMICA SINICA. 15:385-389. Author weblink.
• Ying LM; Xie XS. (10 Dec 1998). Fluorescence spectroscopy, exciton dynamics, and photochemistry of single allophycocyanin trimers. JOURNAL OF PHYSICAL CHEMISTRY B. 102:10399-10409. Author weblink DOI.
• Yu AC; Ying LM; Zhao XS. (1 Sep 1998). Luminescence properties and energy transfer of rare earth(III) complexes. ACTA PHYSICO-CHIMICA SINICA. 14:811-816. Author weblink.
• Zhao YL; Zhou DJ; Huang CH; Gan LB; Ying LM; Zhao XS; Zhang B; Ma Y; et alXu M; Wu K. (20 Jan 1998). Langmuir-Blodgett film of a europium complex and its application in a silver mirror planar microcavity. LANGMUIR. 14:417-422. Author weblink DOI.
• Yu AC; Ying LM; Zhao XS; Xia WS; Huang CH. (1 Dec 1997). Luminescence properties and intramolecular energy transfer of europium (III) complex in Langmuir-Blodgett film. PROGRESS IN NATURAL SCIENCE. 7:692-699. Author weblink.
• Ying LM; Zhao XS. (4 Sep 1997). Theoretical studies of XONO2-H2O (X = Cl, H) complexes. JOURNAL OF PHYSICAL CHEMISTRY A. 101:6807-6812. Author weblink DOI.
• Ying LM; Zhao XS. (8 May 1997). Ab initio and density functional studies of HOBr-H2O and BrONO2-H2O complexes. JOURNAL OF PHYSICAL CHEMISTRY A. 101:3569-3573. Author weblink DOI.
• Shang HR; Gao RM; Ying LM; Zhao XS; Tang YQ. (21 Mar 1997). Laser induced dispersed fluorescence spectra of CH3N radical and the lifetime of its (A)over-tilde(3)E state. CHEMICAL PHYSICS LETTERS. 267:345-350. Author weblink DOI.
• Zhou DJ; Li Q; Huang CH; Yao GQ; Umetani SG; Matsui MK; Ying LM; Yu AC; et alZhao XS. (1 Jan 1997). Room-temperature fluorescence, phosphorescence and crystal structure of 4-acyl pyrazolone lanthanide complexes: Ln(L)(3)center dot 2H(2)O. POLYHEDRON. 16:1381-1389. Author weblink.
• Ying LM; Yu AC; Zhao XS; Li Q; Zhou DJ; Huang CH; Umetani S; Matasai M. (21 Nov 1996). Excited state properties and intramolecular energy transfer of rare-earth acylpyrazolone complexes. JOURNAL OF PHYSICAL CHEMISTRY. 100:18387-18391. Author weblink DOI.
• Ying LM; Xia Y; Shang HR; Zhao XS; Tang YQ. (8 Oct 1996). Photodissociation of methylazide: Observation of triplet methylnitrene radical. JOURNAL OF CHEMICAL PHYSICS. 105:5798-5805. Author weblink DOI.
• SHANG HR; YU C; YING LM; ZHAO XS. (15 Sep 1995). INVESTIGATION OF THE (A)OVER-TILDE (3)E[--](X)OVER-TILDE (3)A(2) SYSTEM OF METHYLNITRENE RADICAL BY LASER SPECTROSCOPY. JOURNAL OF CHEMICAL PHYSICS. 103:4418-4426. Author weblink DOI.
• SHANG HR; YU C; YING LM; ZHAO XS. (14 Apr 1995). DISSOCIATION DYNAMICS OF METHYLAZIDE ON THE FIRST EXCITED SINGLET SURFACE. CHEMICAL PHYSICS LETTERS. 236:318-323. Author weblink DOI.
• YANG HX; YING LM; QIN ZW. (1 Jan 1990). THE STUDY OF MECHANISM FOR THE THERMOLYSIS OF TETRALIN. ACTA CHIMICA SINICA. 48:441-446. Author weblink.

Conferences

• Ying L. Applications of nanopipettes in bionanotechnology. Meeting on Bionanotechnology II - From Biomolecular Assembly to Applications, 7 Jan 2009 - 9 Jan 2009. 37:702-706. PORTLAND PRESS LTD (1 Aug 2009). Author weblink DOI.
• Clarke R; White SS; Ying LM; Klenerman D. Towards single-molecule confinement in physiological solution. 49th Annual Meeting of the Biopysical-Society, 12 Feb 2005 - 16 Feb 2005. 88:520A-520A. BIOPHYSICAL SOCIETY (1 Jan 2005). Author weblink.
• White SS; Ying LM; Balasubramanian S; Klenerman D. Electric field induced conformational switching of a single biomolecule. 48th Annual Meeting of the Biophysical Society, 14 Feb 2004 - 18 Feb 2004. 86:325A-325A. BIOPHYSICAL SOCIETY (1 Jan 2004). Author weblink.
• Gavory G; Li HT; Ying LM; Klenerman D; Balasubramanian S. Identification of a new RNA-RNA interaction site for human telomerase RNA (hTR) by single molecule coincidence spectroscopy. 48th Annual Meeting of the Biophysical Society, 14 Feb 2004 - 18 Feb 2004. 86:144A-144A. BIOPHYSICAL SOCIETY (1 Jan 2004). Author weblink.
• Ying LM; Li HT; Green J; Huppert J; Balasubramanian S; Klenerman D. Single-molecule screening of red dyes. 47th Annual Meeting of the Biophysical-Society, 1 Mar 2003 - 5 Mar 2003. 84:472A-472A. BIOPHYSICAL SOCIETY (1 Feb 2003). Author weblink.