Publications

Journals

• Carafoli F; Mayer MC; Shiraishi K; Pecheva MA; Chan LY; Nan R; Leitinger B; Hohenester E. (4 Apr 2012). Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory fab fragment reveals features important for signaling. Structure. 20:688-697. DOI.
• Valiathan RR; Marco M; Leitinger B; Kleer CG; Fridman R. (26 Feb 2012). Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev. DOI.
• Valencia K; Ormazábal C; Zandueta C; Luis-Ravelo D; Antón I; Pajares MJ; Agorreta J; Montuenga LM; et alMartínez-Canarias S; Leitinger B; Lecanda F. (15 Feb 2012). Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis. Clin Cancer Res. 18:969-980. DOI.
• Leitinger B. (10 Nov 2011). Transmembrane collagen receptors. Annu Rev Cell Dev Biol. 27:265-290. DOI.
• Hidalgo-Carcedo C; Hooper S; Chaudhry SI; Williamson P; Harrington K; Leitinger B; Sahai E. (Jan 2011). Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol. 13:49-58. DOI.
• Xu H; Raynal N; Stathopoulos S; Myllyharju J; Farndale RW; Leitinger B. (Jan 2011). Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol. 30:16-26. DOI.
• Ali BR; Xu H; Akawi NA; John A; Karuvantevida NS; Langer R; Al-Gazali L; Leitinger B. (1 Jun 2010). Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. Hum Mol Genet. 19:2239-2250. DOI.
• Carafoli F; Bihan D; Stathopoulos S; Konitsiotis AD; Kvansakul M; Farndale RW; Leitinger B; Hohenester E. (9 Dec 2009). Crystallographic insight into collagen recognition by discoidin domain receptor 2. Structure. 17:1573-1581. DOI.
• Farndale RW; Lisman T; Bihan D; Hamaia S; Smerling CS; Pugh N; Konitsiotis A; Leitinger B; et alde Groot PG; Jarvis GE; Raynal N. (Apr 2008). Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions. Biochem Soc Trans. 36:241-250. DOI.
• Konitsiotis AD; Raynal N; Bihan D; Hohenester E; Farndale RW; Leitinger B. (14 Mar 2008). Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. J Biol Chem. 283:6861-6868. DOI.
• Leitinger B; Hohenester E. (Apr 2007). Mammalian collagen receptors. Matrix Biol. 26:146-155. DOI.
• Noordeen NA; Carafoli F; Hohenester E; Horton MA; Leitinger B. (11 Aug 2006). A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. J Biol Chem. 281:22744-22751. DOI.
• Leitinger B; Kwan AP. (Aug 2006). The discoidin domain receptor DDR2 is a receptor for type X collagen. Matrix Biol. 25:355-364. DOI.
• Leitinger, B.; Steplewski, A.; Fertala, A.. (2004). The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. J. Mol. Biol. 344:993-1003. Author weblink.
• Leitinger, B. (May 2003). Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2 - Identification of collagen binding sites in DDR2. J Biol Chem. 19, 278:16761-16769. Author weblink.
• McDowall, A.; Inwald, D.; Leitinger, B.; Jones, A.; Liesner, R.; Klein, N.; Hogg, N.. (2003). A novel form of integrin dysfunction involving beta1, beta2 and beta3 integrins. J. Clin. Invest. 1, 111:51-60. Author weblink.
• Smith, A.; Bracke, M.; Leitinger, B.; Porter, J.C; Hogg, N. (2003). LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK dependent detachment. J. Cell Sci. 116:3123-3133. Author weblink.
• Hogg, N.; Henderson, R.; Leitinger, B.; McDowall, A.; Porter, J.; Stanley, P.. (2002). Mechanisms contributing to the activity of integrins on leukocytes. Immunol. Rev. 186:164-171. Author weblink.
• Leitinger, B.; Hogg, N.. (2002). The involvement of lipid rafts in the regulation of integrin function. J. Cell. Sci. 5, 115:963-972. Author weblink.
• Hogg, N.; Leitinger, B. (2001). Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1. J. Leuk. Biol. 69:893-898. Author weblink.
• Leitinger, B; Hogg, N. (2000). Effects of I domain deletion on the function of the β2 integrin lymphocyte function-associated antigen-1. Mol. Biol. Cell. 11:677-690.
• Leitinger, B; Hogg, N. (2000). From crystal clear ligand binding to designer I domains. Nat. Struct. Biol. 7:614-616.
• Leitinger, B; McDowall, A; Stanley, P; Hogg, N. (2000). The regulation of integrin function by Ca2+. Biochim. Biophys. Acta. 1498:91-98.
• Leitinger, B; Hogg, N. (1999). Integrin I domains and their function. Biochem. Soc. Trans. 27:826-832.
• McDowall, A; Leitinger, B; Stanley, P; Bates, P A; Randi, A M; Hogg, N. (1998). The I domain of integrin leukocyte function-associated antigen-1 is involved in a conformational change leading to high affinity binding to ligand intercellular adhesion molecule-1 (ICAM-1). J. Biol. Chem. 273:27396-27403.
• Leitinger, B; Hille-Rehfeld, A; Spiess, M. (1995). Biosynthetic transport of the asialoglycoprotein receptor H1 to the cell surface occurs via endosomes. Proc. Natl. Acad. Sci. USA. 92:10109-10113.
• Bergler, H; Wallner, P; Ebeling, A; Leitinger, B; Fuchsbichler, S; Aschauer, H; Kollenz, G; Hogenauer, G; et alTurnowsky, F. (1994). Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli. J. Biol. Chem. 269:5493-5496.
• Leitinger, B; Brown, J; Spiess, M. (1994). Tagging secretory and membrane proteins with a tyrosine sulfation site. J. Biol. Chem. 269:8115-8121.
• Geffen, I; Fuhrer, C; Leitinger, B; Weiss, M; Huggel, K; Griffiths, G; Spiess, M. (1993). Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor. J. Biol. Chem. 268:20772-20777.